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GATA-3 controls self-renewal in stressed HSCs

Nature Immunology volume 14, pages 10321033 (2013) | Download Citation

The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.

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Author information

Affiliations

  1. Toshimi Yoshida and Katia Georgopoulos are in the Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

    • Toshimi Yoshida
    •  & Katia Georgopoulos

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Katia Georgopoulos.

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DOI

https://doi.org/10.1038/ni.2715

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