The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Trumpp, A., Essers, M. & Wilson, A. Nat. Rev. Immunol. 10, 201–209 (2010).
King, K.Y. & Goodell, M.A. Nat. Rev. Immunol. 11, 685–692 (2011).
Cheng, T. et al. Science 287, 1804–1808 (2000).
Frelin, C. et al. Nat. Immunol. 14, 1037–1044 (2013).
Kiel, M.J., Yilmaz, O.H., Iwashita, T., Terhorst, C. & Morrison, S.J. Cell 121, 1109–1121 (2005).
Benveniste, P. et al. Cell Stem Cell 6, 48–58 (2010).
Ito, K. et al. Nat. Med. 12, 446–451 (2006).
Buza-Vidas, N. et al. Blood 118, 1291–1293 (2011).
Ku, C.J., Hosoya, T., Maillard, I. & Engel, J.D. Blood 119, 2242–2251 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Yoshida, T., Georgopoulos, K. GATA-3 controls self-renewal in stressed HSCs. Nat Immunol 14, 1032–1033 (2013). https://doi.org/10.1038/ni.2715
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2715