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DCs: a dual bridge to protective immunity

CD11b+ dendritic cells (DCs) represent a subset of classical DCs that require signaling via the receptor Notch2 and lymphotoxin-β receptor and act as obligate source of interleukin 23 for protection against Citrobacter rodentium.

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Figure 1: DCs serve as a dual bridge between pathogen recognition and effector cells of both the innate and adaptive immune system.

Marina Corral Spence

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Correspondence to Federica Sallusto.

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Sallusto, F. DCs: a dual bridge to protective immunity. Nat Immunol 14, 890–891 (2013). https://doi.org/10.1038/ni.2693

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