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The IL-20 cytokine subfamily: bad guys in host defense?

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Resistance to infection of the skin with Staphylococcus aureus depends on early production of interleukin 1β (IL-1β) and IL-17A by skin-resident cells. However, several members of the IL-20 subfamily of cytokines (IL-19, IL-20 and IL-24) can inhibit the local generation of those two cytokines.

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Figure 1: Model for inhibition of the production of IL-1β and IL-17A via IL-20R during infection with S. aureus.

Marina Corral Spence

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Correspondence to Daniel H Kaplan.

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The author declares no competing financial interests.

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Kaplan, D. The IL-20 cytokine subfamily: bad guys in host defense?. Nat Immunol 14, 774–775 (2013). https://doi.org/10.1038/ni.2664

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