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PLA2G3 promotes mast cell maturation and function

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The mast cell–derived phospholipase PLA2G3 and fibroblast prostaglandin synthase contribute to a mast cell–fibroblast paracrine axis dependent on the prostaglandin PGD2 and its receptor DP1 that can enhance the maturation and mediator secretion of mast cells.

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Figure 1: Endogenous PLA2G3 can promote mast cell maturation and induce and enhance mast cell activation.

Katie Vicari

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Correspondence to Stephen J Galli.

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Starkl, P., Marichal, T. & Galli, S. PLA2G3 promotes mast cell maturation and function. Nat Immunol 14, 527–529 (2013). https://doi.org/10.1038/ni.2612

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