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Slc7a5 helps T cells get with the program

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T cell activation requires an influx of amino acids. Slc7a5, an amino-acid transporter induced by the T cell antigen receptor, facilitates the influx of large neutral amino acids and in doing so promotes metabolic reprogramming necessary for T cell differentiation.

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Figure 1: Slc7a5 promotes the proliferation and differentiation of T cells by reprogramming metabolism.

References

  1. Jones, R.G. & Thompson, C.B. Immunity 27, 173–178 (2007).

    Article  CAS  Google Scholar 

  2. Sinclair, L.V. et al. Nat. Immunol. 14, 500–508 (2013).

    Article  CAS  Google Scholar 

  3. Waickman, A.T. & Powell, J.D. Immunol. Rev. 249, 43–58 (2012).

    Article  CAS  Google Scholar 

  4. Frauwirth, K.A. et al. Immunity 16, 769–777 (2002).

    Article  CAS  Google Scholar 

  5. Verrey, F. et al. Pflugers Arch. 447, 532–542 (2004).

    Article  CAS  Google Scholar 

  6. Zoncu, R., Efeyan, A. & Sabatini, D.M. Nat. Rev. Mol. Cell Biol. 12, 21–35 (2011).

    Article  CAS  Google Scholar 

  7. Heikamp, E.B. & Powell, J.D. Semin. Immunol. 24, 414–420 (2013).

    Article  Google Scholar 

  8. Wang, R. et al. Immunity 35, 871–882 (2011).

    Article  CAS  Google Scholar 

  9. Finlay, D.K. et al. J. Exp. Med. 209, 2441–2453 (2012).

    Article  CAS  Google Scholar 

  10. Thoreen, C.C. et al. J. Biol. Chem. 284, 8023–8032 (2009).

    Article  CAS  Google Scholar 

  11. Munn, D.H. & Mellor, A.L. Trends Immunol. 34, 137–143 (2012).

    Article  Google Scholar 

  12. Angelini, G. et al. Proc. Natl. Acad. Sci. USA 99, 1491–1496 (2002).

    Article  CAS  Google Scholar 

  13. Cobbold, S.P. et al. Proc. Natl. Acad. Sci. USA 106, 12055–12060 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Jonathan D Powell.

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The author declares no competing financial interests.

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Powell, J. Slc7a5 helps T cells get with the program. Nat Immunol 14, 422–424 (2013). https://doi.org/10.1038/ni.2594

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