Obesity induces metabolic stress and is associated with inflammation. A cellular pathway now links SIRT2, a deacetylase involved in metabolic processes, to cytoskeleton remodelling and activation of the NLRP3 inflammasome.
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Donath, M. When metabolism met immunology. Nat Immunol 14, 421–422 (2013). https://doi.org/10.1038/ni.2591
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DOI: https://doi.org/10.1038/ni.2591
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