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Immune response: steroids drive dendritic cells

Nature Immunology volume 14, pages 424426 (2013) | Download Citation

The newly identified steroid ligand of the receptor EBI2 (GPCR183), 7α,25-dihydroxycholesterol, is required for the positioning of splenic CD4+ dendritic cells in bridging channels to prime T cells for an efficient antibody response.

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Author information

Affiliations

  1. David Jarrossay and Marcus Thelen are at the Institute for Research in Biomedicine, Bellinzona, Switzerland.

    • David Jarrossay
    •  & Marcus Thelen

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to David Jarrossay or Marcus Thelen.

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DOI

https://doi.org/10.1038/ni.2589

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