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An inside job for antibodies: tagging pathogens for intracellular sensing

Nature Immunology volume 14, pages 309311 (2013) | Download Citation

Antibodies bound to pathogens that invade cells are sensed in the cytosol by the receptor TRIM21, which triggers innate signaling that leads to protective immunity.

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Author information

Affiliations

  1. Teunis B.H. Geijtenbeek and Sonja I. Gringhuis are in the Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

    • Teunis B H Geijtenbeek
    •  & Sonja I Gringhuis

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Teunis B H Geijtenbeek.

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DOI

https://doi.org/10.1038/ni.2574

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