Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

High-affinity IgA needs TH17 cell functional plasticity

The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: TH17 cells convert into IgA-inducing TFH cells in the intestinal mucosa.

Katie vicari

References

  1. Honda, K. & Littman, D.R. Annu. Rev. Immunol. 30, 759–795 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Fagarasan, S. et al. Science 298, 1424–1427 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Kawamoto, S. et al. Science 336, 485–489 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. Hirota, K. et al. Nat. Immunol. 14, 372–379 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hooper, L.V., Littman, D.R. & Macpherson, A.J. Science 336, 1268–1273 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Ivanov, I.I. et al. Cell 139, 485–498 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hirota, K. et al. Nat. Immunol. 12, 255–263 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. McHeyzer-Williams, M., Okitsu, S., Wang, N. & McHeyzer-Williams, L. Nat. Rev. Immunol. 12, 24–34 (2012).

    Article  CAS  Google Scholar 

  10. Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    Article  CAS  PubMed  Google Scholar 

  11. Tsuji, M. et al. Science 323, 1488–1492 (2009).

    Article  CAS  PubMed  Google Scholar 

  12. Wang, N.S. et al. Nat. Immunol. 13, 604–611 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael G McHeyzer-Williams.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Milpied, P., McHeyzer-Williams, M. High-affinity IgA needs TH17 cell functional plasticity. Nat Immunol 14, 313–315 (2013). https://doi.org/10.1038/ni.2567

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2567

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing