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High-affinity IgA needs TH17 cell functional plasticity

Nature Immunology volume 14, pages 313315 (2013) | Download Citation

The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.

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Author information

Affiliations

  1. Pierre J. Milpied and Michael G. McHeyzer-Williams are in the Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla California, USA.

    • Pierre J Milpied
    •  & Michael G McHeyzer-Williams

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael G McHeyzer-Williams.

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DOI

https://doi.org/10.1038/ni.2567

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