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Myeloid-cell differentiation redefined in cancer

Nature Immunology volume 14, pages197–199(2013)Cite this article

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The differentiation of monocytes is altered in cancer, which results in the unexpected conversion of a large proportion of monocytic myeloid-derived suppressor cells into polymorphonuclear myeloid-derived suppressor cells.

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Figure 1: M-MDSCs differentiate into PMN-MDSCs in tumor-bearing hosts.

Marina Corral

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Affiliations

  1. Thomas A. Wynn is in the Immunopathogenesis Section, Program in Tissue Immunity and Repair and the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

    Thomas A Wynn

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  1. Thomas A Wynn
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Correspondence to Thomas A Wynn.

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The author declares no competing financial interests.

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Wynn, T. Myeloid-cell differentiation redefined in cancer. Nat Immunol 14, 197–199 (2013). https://doi.org/10.1038/ni.2539

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