Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Myeloid-cell differentiation redefined in cancer

The differentiation of monocytes is altered in cancer, which results in the unexpected conversion of a large proportion of monocytic myeloid-derived suppressor cells into polymorphonuclear myeloid-derived suppressor cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: M-MDSCs differentiate into PMN-MDSCs in tumor-bearing hosts.

Marina Corral


  1. 1

    Joyce, J.A. & Pollard, J.W. Nat. Rev. Cancer 9, 239–252 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Sica, A. & Bronte, V. J. Clin. Invest. 117, 1155–1166 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Gabrilovich, D.I., Ostrand-Rosenberg, S. & Bronte, V. Nat. Rev. Immunol. 12, 253–268 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Gabrilovich, D.I. et al. Nat. Immunol. 14, 211–220 (2013).

    PubMed  PubMed Central  Google Scholar 

  5. 5

    Movahedi, K. et al. Blood 111, 4233–4244 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Galli, S.J., Borregaard, N. & Wynn, T.A. Nat. Immunol. 12, 1035–1044 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Miller, J.C. et al. Nat. Immunol. 13, 888–899 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Chen, H.Z., Tsai, S.Y. & Leone, G. Nat. Rev. Cancer 9, 785–797 (2009).

    CAS  Article  Google Scholar 

  9. 9

    Viatour, P. et al. Cell Stem Cell 3, 416–428 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Walkley, C.R., Shea, J.M., Sims, N.A., Purton, L.E. & Orkin, S.H. Cell 129, 1081–1095 (2007).

    CAS  Article  Google Scholar 

  11. 11

    Minucci, S. & Pelicci, P.G. Nat. Rev. Cancer 6, 38–51 (2006).

    CAS  Article  Google Scholar 

  12. 12

    Filipazzi, P. et al. J. Clin. Oncol. 25, 2546–2553 (2007).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Thomas A Wynn.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wynn, T. Myeloid-cell differentiation redefined in cancer. Nat Immunol 14, 197–199 (2013).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing