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Just say NO to NLRP3

Nature Immunology volume 14, pages 12–14 (2013)Cite this article

Feedback inhibition by interferon-γ blocks the NLRP3 inflammasome by triggering inducible nitric oxide synthase (iNOS), and the resulting nitric oxide (NO) thio-nitrosylates NLRP3, shutting it down. This prevents excessive immunopathology during chronic infection with Mycobacterium tuberculosis.

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Figure 1: Thio-nitrosylation by NO inhibits the NLRP3 inflammasome.

References

  1. Mishra, B.B. et al. Nat. Immunol. 14, 52–60 (2013).

    Article  CAS  PubMed  Google Scholar 

  2. Hernandez-Cuellar, E. et al. J. Immunol. advance online publication, doi:10.4049/jimmunol.1202479 (24 October 2012).

  3. MacMicking, J.D. Nat. Rev. Immunol. 12, 367–382 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Schroder, K. et al. Immunobiology 217, 1325–1329 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Juliana, C. et al. J. Biol. Chem. 287, 36617–36622 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bauernfeind, F.G. et al. J. Immunol. 183, 787–791 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Kastenmüller, W., Torabi-Parizi, P., Subramanian, N., Lämmermann, T. & Germain, R.N. Cell 150, 1235–1248 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Rayamajhi, M., Humann, J., Penheiter, K., Andreasen, K. & Lenz, L.L. J. Exp. Med. 207, 327–337 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Jones, J.W. et al. Proc. Natl. Acad. Sci. USA 107, 9771–9776 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Guarda, G. et al. Immunity 34, 213–223 (2011).

    Article  CAS  PubMed  Google Scholar 

  11. Inoue, M. et al. Sci. Signal. 5, ra38 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kayagaki, N. et al. Nature 479, 117–121 (2011).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Manira Rayamajhi and Edward A. Miao are in the Department of Microbiology and Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Manira Rayamajhi & Edward A Miao

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  1. Manira Rayamajhi
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  2. Edward A Miao
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Correspondence to Edward A Miao.

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The authors declare no competing financial interests.

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Rayamajhi, M., Miao, E. Just say NO to NLRP3. Nat Immunol 14, 12–14 (2013). https://doi.org/10.1038/ni.2493

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