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Innate sensing of bacterial cyclic dinucleotides: more than just STING

Bacterial cyclic dinucleotides are recognized by the innate immune system, and this leads to the induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway to the induction of type I interferons.

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Figure 1: A mechanism whereby DDX41 senses bacterial CDNs and dsDNA to mediate the induction of type I interferons.

Debbie Maizels

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Correspondence to Andrew G Bowie.

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Bowie, A. Innate sensing of bacterial cyclic dinucleotides: more than just STING. Nat Immunol 13, 1137–1139 (2012). https://doi.org/10.1038/ni.2469

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