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Immunology beats cancer: a blueprint for successful translation

Abstract

Immunology offers an unprecedented opportunity for the science-driven development of therapeutics. The successes of antibodies to the immunomodulatory receptor CTLA-4 and blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene discovery to patient benefit, have created a paradigm for driving such endeavors.

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Figure 1: Parallel timelines and milestones of the development of therapies involving anti-CTLA-4 and anti-PD-1, from gene discovery through clinical development.

Katie Vicari

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Correspondence to Drew M Pardoll.

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Pardoll, D. Immunology beats cancer: a blueprint for successful translation. Nat Immunol 13, 1129–1132 (2012). https://doi.org/10.1038/ni.2392

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