The yin-yang nature of CSF1R-binding cytokines

Most myeloid cells express the growth-factor receptor CSF1R. Recognition of interleukin 34 by CSF1R is required for the development of tissue-resident Langerhans cells and microglia, which explains the independence of their growth from CSF1.

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Figure 1: IL-34-dependent development of LCs and microglia.

Katie Vicari

References

  1. 1

    Wang, Y. et al. Nat. Immunol. 13, 753–760 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Hamilton, J.A. Nat. Rev. Immunol. 8, 533–544 (2008).

    CAS  Article  Google Scholar 

  3. 3

    Yoshida, H. et al. Nature 345, 442–444 (1990).

    CAS  Article  Google Scholar 

  4. 4

    Ginhoux, F. et al. Nat. Immunol. 7, 265–273 (2006).

    CAS  Article  Google Scholar 

  5. 5

    Witmer-Pack, M.D. et al. J. Cell Sci. 104, 1021–1029 (1993).

    PubMed  PubMed Central  Google Scholar 

  6. 6

    Ginhoux, F. et al. Science 330, 841–845 (2010).

    CAS  Article  Google Scholar 

  7. 7

    Lin, H. et al. Science 320, 807–811 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Ma, X. et al. Structure 20, 676–687 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Wei, S. et al. J. Leukoc. Biol. 88, 495–505 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Kissenpfennig, A. et al. Immunity 22, 643–654 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Kaplan, D.H., Jenison, M.C., Saeland, S., Shlomchik, W.D. & Shlomchik, M.J. Immunity 23, 611–620 (2005).

    CAS  Article  Google Scholar 

  12. 12

    Kautz-Neu, K. et al. J. Exp. Med. 208, 885–891 (2011).

    CAS  Article  Google Scholar 

  13. 13

    Ransohoff, R.M. & Cardona, A.E. Nature 468, 253–262 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Paola Ricciardi-Castagnoli.

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Zelante, T., Ricciardi-Castagnoli, P. The yin-yang nature of CSF1R-binding cytokines. Nat Immunol 13, 717–719 (2012). https://doi.org/10.1038/ni.2375

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