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The yin-yang nature of CSF1R-binding cytokines

Nature Immunology volume 13, pages 717–719 (2012)Cite this article

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Most myeloid cells express the growth-factor receptor CSF1R. Recognition of interleukin 34 by CSF1R is required for the development of tissue-resident Langerhans cells and microglia, which explains the independence of their growth from CSF1.

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Figure 1: IL-34-dependent development of LCs and microglia.

Katie Vicari

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Authors and Affiliations

  1. Teresa Zelante and Paola Ricciardi-Castagnoli are with the Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore.,

    Teresa Zelante & Paola Ricciardi-Castagnoli

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  1. Teresa Zelante
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  2. Paola Ricciardi-Castagnoli
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Correspondence to Paola Ricciardi-Castagnoli.

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The authors declare no competing financial interests.

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Zelante, T., Ricciardi-Castagnoli, P. The yin-yang nature of CSF1R-binding cytokines. Nat Immunol 13, 717–719 (2012). https://doi.org/10.1038/ni.2375

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