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IRF3: a molecular switch in pathogen responses

Nature Immunology volume 13, pages 634–635 (2012)Cite this article

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Antiviral innate immunity often has deleterious effects on the course of bacterial infection. Activation of the transcription factor IRF3 induced by the recognition of double-stranded RNA by RIG-I-like receptors suppresses the Toll-like receptor–induced expression of interleukins 12 and 23 and antibacterial responses.

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Figure 1: Suppression of expression of Il12b by IRF3.

Katie Vicari

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Authors and Affiliations

  1. Osamu Takeuchi is in the Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto, Japan.,

    Osamu Takeuchi

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  1. Osamu Takeuchi
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Correspondence to Osamu Takeuchi.

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The author declares no competing financial interests.

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Takeuchi, O. IRF3: a molecular switch in pathogen responses. Nat Immunol 13, 634–635 (2012). https://doi.org/10.1038/ni.2346

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