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Immunological complications of obesity

Abstract

Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.

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Figure 1: Obesity-associated diseases linked to complications of the immune system.

Marina Corral

Figure 2: Immune system–metabolic system interactions in obesity.
Figure 3: Inflammasomes fuel obesity-induced inflammation.

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Acknowledgements

We thank J. Lukens for discussions and help in preparing the manuscript. Supported by the US National Institutes of Health (AR056296 and AI101935 to T.-D.K.; NIA-AG031797 and NIDDK-090556 to V.D.D.), the American Lebanese Syrian Associated Charities (T.-D.K.) and the Pennington Biomedical Research Foundation (V.D.D.).

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Correspondence to Thirumala-Devi Kanneganti or Vishwa Deep Dixit.

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Kanneganti, TD., Dixit, V. Immunological complications of obesity. Nat Immunol 13, 707–712 (2012). https://doi.org/10.1038/ni.2343

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