The role of the coreceptor CD28 in thymic clonal deletion has been controversial. New evidence suggests that CD28 deficiency impairs the clonal deletion of self-reactive T cells but also results in their developmental diversion to an anergic lineage that ends up in the gut.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Walunas, T.L., Sperling, A.I., Khattri, R., Thompson, C.B. & Bluestone, J.A. J. Immunol. 156, 1006–1013 (1996).
Stritesky, G.L., Jameson, S.C. & Hogquist, K.A. Annu. Rev. Immunol. 30, 95–114 (2012).
Pobezinsky, L.A. et al. Nat. Immunol. 13, 569–578 (2012).
Gangadharan, D. et al. Immunity 25, 631–641 (2006).
Jiang, W., Ferrero, I., Laurenti, E., Trumpp, A. & MacDonald, H.R. Blood 115, 4431–4438 (2010).
Kennedy, M.K. et al. J. Exp. Med. 191, 771–780 (2000).
Suzuki, H., Duncan, G.S., Takimoto, H. & Mak, T.W. J. Exp. Med. 185, 499–505 (1997).
Sato, T. et al. Immunity 22, 317–328 (2005).
Rocha, B., Vassalli, P. & Guy-Grand, D. J. Exp. Med. 173, 483–486 (1991).
Hayday, A. & Gibbons, D. Mucosal Immunol. 1, 172–174 (2008).
Casey, K.A. et al. J. Immunol. doi:10.4049/jimmunol.1200402 (13 April 2012).
Olivares-Villagómez, D. & Van Kaer, L. Immunol. Lett. 134, 1–6 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Stritesky, G., Hogquist, K. Death diverted, but to what?. Nat Immunol 13, 528–530 (2012). https://doi.org/10.1038/ni.2311
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2311
This article is cited by
-
CD8αα intraepithelial lymphocytes arise from two main thymic precursors
Nature Immunology (2017)