In the gut, cells of the immune system must tolerate commensal bacteria but also detect pathogens. To achieve this, intestinal phagocytes are hyporesponsive to Toll-like receptor stimulants released from commensals, but can detect invasion of pathogens via the intracellular NLRC4 inflammasome.
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Franklin, B., Latz, E. For gut's sake: NLRC4 inflammasomes distinguish friend from foe. Nat Immunol 13, 429–431 (2012). https://doi.org/10.1038/ni.2289
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DOI: https://doi.org/10.1038/ni.2289
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