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An invariant road to cross-presentation

Nature Immunology volume 13, pages 207208 (2012) | Download Citation

The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules.

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Affiliations

  1. Fei Duan and Pramod K. Srivastava are with the Department of Immunology and the Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

    • Fei Duan
    •  & Pramod K Srivastava

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Competing interests

The authors declare no competing financial interests.

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Correspondence to Pramod K Srivastava.

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DOI

https://doi.org/10.1038/ni.2235

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