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An invariant road to cross-presentation

Nature Immunology volume 13, pages 207–208 (2012)Cite this article

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The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules.

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Figure 1: Pathways of trafficking of MHC class I and peptides during cross-presentation.

Katie Vicari

References

  1. Morrison, L., Lukacher, A., Braciale, V., Fan, D. & Braciale, T. J. Exp. Med. 163, 903–921 (1986).

    Article  CAS  Google Scholar 

  2. Neefjes, J., Jongsma, M., Paul, P. & Bakke, O. Nat. Rev. Immunol. 11, 823–836 (2011).

    Article  CAS  Google Scholar 

  3. Basha, G. et al. Nat. Immunol. 12, 237–245 (2012).

    Article  Google Scholar 

  4. Roche, P.A. & Cresswell, P. Nature 345, 615–618 (1990).

    Article  CAS  Google Scholar 

  5. Bevan, M.J. Nat. Immunol. 7, 363–365 (2006).

    Article  CAS  Google Scholar 

  6. Amigorena, S. & Savina, A. Curr. Opin. Immunol. 22, 109–117 (2010).

    Article  CAS  Google Scholar 

  7. Binder, R.J. & Srivastava, P.K. Nat. Immunol. 6, 593–599 (2005).

    Article  CAS  Google Scholar 

  8. Lev, A. et al. Immunity 28, 787–798 (2008).

    Article  CAS  Google Scholar 

  9. Delamarre, L., Pack, M., Chang, H., Mellman, I. & Trombetta, E.S. Science 307, 1630–1634 (2005).

    Article  CAS  Google Scholar 

  10. Mantegazza, A.R. et al. Blood 112, 4712–4722 (2008).

    Article  CAS  Google Scholar 

  11. Sugita, M. & Brenner, M.B. J. Biol. Chem. 270, 1443–1448 (1995).

    Article  CAS  Google Scholar 

  12. Belizaire, R. & Unanue, E.R. Proc. Natl. Acad. Sci. USA 106, 17463–17468 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Fei Duan and Pramod K. Srivastava are with the Department of Immunology and the Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, Connecticut, USA.,

    Fei Duan & Pramod K Srivastava

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  1. Fei Duan
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  2. Pramod K Srivastava
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Correspondence to Pramod K Srivastava.

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Duan, F., Srivastava, P. An invariant road to cross-presentation. Nat Immunol 13, 207–208 (2012). https://doi.org/10.1038/ni.2235

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