Since the definition of an immunoselective proteasome, the 'immunoproteasome', its function has been heavily disputed. A mouse with complete deficiency in immunoproteasomes has resolved one issue of the adaptation of the immune system to the proteasome but has raised other questions.
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Spaapen, R., Neefjes, J. Immuno-waste exposure and further management. Nat Immunol 13, 109–111 (2012). https://doi.org/10.1038/ni.2204
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DOI: https://doi.org/10.1038/ni.2204
