Abstract
The view that immunoglobulins function largely by potentiating neutralization, cytotoxicity or phagocytosis is being replaced by a new synthesis whereby antibodies participate in all aspects of the immune response, from protecting the host at the earliest time of encounter with a microbe to later challenges. Perhaps the most transformative concept is that immunoglobulins manifest emergent properties, from their structure and function as individual molecules to their interactions with microbial targets and the host immune system. Given that emergent properties are neither reducible to first principles nor predictable, there is a need for new conceptual approaches for understanding antibody function and mechanisms of antibody immunity.
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Acknowledgements
We thank M.D. Scharff for critical reading of this manuscript and suggestions. Supported by the US National Institutes of Health (AI45459, AI44374, AI033774 and HL059842) and the Northeastern Biodefense Center (5U54AI057158-08 – Lipkin to A.D.).
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Casadevall, A., Pirofski, La. A new synthesis for antibody-mediated immunity. Nat Immunol 13, 21–28 (2012). https://doi.org/10.1038/ni.2184
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DOI: https://doi.org/10.1038/ni.2184
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