News & Views | Published:

STING-dependent signaling

Nature Immunology volume 12, pages 929930 (2011) | Download Citation

  • A Corrigendum to this article was published on 19 January 2012

This article has been updated

The sensing of pathogen-associated DNA in the cytoplasm is an important trigger of host-defense responses that include the production of type I interferon. A new study suggests that the DExDc helicase DDX41 may function in dendritic cells as a DNA sensor to activate STING-dependent innate immune responses.

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  • 17 November 2011

    In the version of this News & Views initially published, the sensor DDX41 was reported to recognize Z-form DNA in addition to conventional B-form DNA. This finding remains inconclusive as it was not shown that the GC-rich oligonucleotides used the original study actually adopted the Z-DNA conformation. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1.

    , & Int. Rev. Immunol. 30, 16–34 (2011).

  2. 2.

    et al. Nat. Immunol. 12, 959–965 (2011).

  3. 3.

    , , & J. Interferon Cytokine Res. 30, 875–881 (2010).

  4. 4.

    & Science 327, 284–286 (2010).

  5. 5.

    , & Cell Res. 16, 141–147 (2006).

  6. 6.

    & Cell. Mol. Life Sci. 68, 1157–1165 (2011).

  7. 7.

    & Cell 140, 821–832 (2010).

  8. 8.

    & Nature 455, 674–678 (2008).

  9. 9.

    , & Nature 461, 788–792 (2009).

  10. 10.

    et al. Nature 448, 501–505 (2007).

  11. 11.

    et al. Nat. Immunol. 11, 997–1004 (2010).

  12. 12.

    et al. Infect. Immun. 79, 688–694 (2011).

Download references

Author information

Affiliations

  1. Glen N. Barber is in the Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, USA.

    • Glen N Barber

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The author declares no competing financial interests.

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Correspondence to Glen N Barber.

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DOI

https://doi.org/10.1038/ni.2118

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