Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IL-17R signaling: new players get in on the Act1

Proinflammatory signaling by the interleukin 17 receptor requires the adaptor Act1. Two studies identify an additional function for Act1 and identify new participants that regulate the inflammatory effects of IL-17.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: TRAF6-dependent and TRAF6-independent IL-17R signaling pathways.


  1. Chang, S.H. & Dong, C. Cell. Signal. 23, 1069–1075 (2011).

    Article  CAS  Google Scholar 

  2. Zepp, J., Wu, L. & Li, X. Trends Immunol. 32, 232–239 (2011).

    Article  CAS  Google Scholar 

  3. Bulek, K. et al. Nat. Immunol. 12, 853–860 (2011).

    Article  Google Scholar 

  4. Sun, D. et al. Nat. Immunol. 12, 844–852 (2011).

    Article  Google Scholar 

  5. Qian, Y. et al. Nat. Immunol. 8, 247–256 (2007).

    Article  CAS  Google Scholar 

  6. Swaidani, S. et al. J. Immunol. 182, 1631–1640 (2009).

    Article  CAS  Google Scholar 

  7. Liu, C. et al. Sci. Signal. 2, ra63 (2009).

    PubMed  PubMed Central  Google Scholar 

  8. Hartupee, J., Liu, C., Novotny, M., Li, X. & Hamilton, T. J. Immunol. 179, 4135–4141 (2007).

    Article  CAS  Google Scholar 

  9. Hartupee, J. et al. J. Immunol. 182, 1660–1666 (2009).

    Article  CAS  Google Scholar 

  10. Fitzgerald, K.A. et al. Nat. Immunol. 4, 491–496 (2003).

    Article  CAS  Google Scholar 

  11. Datta, S. et al. J. Immunol. 184, 1484–1491 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michael J May.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

May, M. IL-17R signaling: new players get in on the Act1. Nat Immunol 12, 813–815 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing