Tuberins, the tumor-suppressor proteins that regulate signaling via the kinase mTOR, now emerge as essential enforcers of T cell quiescence that promote survival.
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References
Nourse. J., et al. Nature 372, 570–573 (1994).
Kuo, C.T., Veselits, M.L. & Leiden, J.M. Science 277, 1986–1990 (1997).
Berger, M. et al. Nat. Immunol. 11, 335–343 (2010).
Yang, K., Neale, G., Green, D.R., He, W. & Chi, H. Nat. Immunol. 12, 888–897 (2011).
Wu, Q., et al. J. Immunol., 187, 1106–1112 (2011).
Wullschleger, S., Loewith, R. & Hall, M. Cell 124, 471–484 (2006).
Chen, C. et al. J. Exp. Med. 205, 2397–2408 (2008).
Cunningham, J.T. et al. Nature 450, 736–740 (2007).
Zhou, X. et al. Proc. Natl. Acad. Sci. USA 106, 8923–8928 (2009).
Lee, K. et al. Immunity 32, 743–753 (2010).
Delgoffe, G.M. et al. Nat. Immunol. 12, 295–303 (2011).
Lacher, M.D. et al. Oncogene 29, 6543–6556 (2010).
Kerdiles, Y.M. et al. Nat. Immunol. 10, 176–184 (2009).
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Boothby, M., Lee, K. A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS. Nat Immunol 12, 811–812 (2011). https://doi.org/10.1038/ni.2092
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DOI: https://doi.org/10.1038/ni.2092
