IDO: more than an enzyme

Article metrics

In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-β (TGF-β), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Distinct functions for IDO in pDCs in response to IFN-γ or TGF-β.

Katie Vicari

References

  1. 1

    Mellor, A.L. & Munn, D.H. Natl. Rev. 4, 762 (2004).

  2. 2

    Pallota, M.T. et al. Nat. Immunol. 12, 870–878 (2011).

  3. 3

    Colonna, M., Trinchieri, G. & Liu, Y.J. Nat. Immunol. 5, 1219 (2004).

  4. 4

    Reizis, B. et al. Annu. Rev. Immunol. 29, 163 (2011).

  5. 5

    Belladonna, M.L. et al. J. Immunol. 181, 5194 (2008).

  6. 6

    Chen, W. et al. J. Exp. Med. 198, 1875 (2003).

  7. 7

    Orabona, C. et al. Nat. Immunol. 5, 1134 (2004).

  8. 8

    Neel, B.G., Gu, H. & Pao, L. Trends Biochem. Sci. 28, 284 (2003).

  9. 9

    Shi, Y. & Massague, J. Cell 113, 685 (2003).

  10. 10

    Belladonna, M.L. et al. Trends Mol. Med. 15, 41 (2009).

  11. 11

    Grohmann, U. et al. Nat. Immunol. 3, 1097 (2002).

Download references

Author information

Correspondence to WanJun Chen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Further reading