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SHP works a double shift to control TLR signaling

Nature Immunology volume 12, pages 725727 (2011) | Download Citation

Innate immune responses need to be tightly controlled to avoid autoimmune and inflammatory diseases. The atypical orphan nuclear receptor SHP has now been identified as a negative regulator of Toll-like receptor–induced activation of the transcription factor NF-κB.

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Author information

Affiliations

  1. Rudi Beyaert is at the Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium, and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

    • Rudi Beyaert

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Rudi Beyaert.

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DOI

https://doi.org/10.1038/ni.2075

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