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NF-κB is 25

NF-κB-mediated inflammatory biology can be formulated as the following five states: latency, induction, response, resolution and pathology. The first four involve carefully tuned molecular processes; pathology is the loss of control.

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References

  1. Sen, R. & Baltimore, D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. J. Immunol. 177, 7485–7496 (2006).

    CAS  PubMed  Google Scholar 

  2. Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428–435 (2008).

    Article  CAS  Google Scholar 

  3. Smale, S.T. Hierarchies of NF-κB target-gene regulation. Nat. Immunol. 12, 689–694 (2011).

    Article  CAS  Google Scholar 

  4. Oeckinghaus, A., Hayden, M.S. & Ghosh, S. Crosstalk in NF-κB signaling pathways. Nat. Immunol. 12, 695–708 (2011).

    Article  CAS  Google Scholar 

  5. Leung, T.H., Hoffmann, A. & Baltimore, D. One nucleotide in a kB site can determine cofactor specificity for NF-κB dimers. Cell 118, 453–464 (2004).

    Article  CAS  Google Scholar 

  6. Sen, R. The origins of NF-κB. Nat. Immunol. 12, 686–688 (2011).

    Article  CAS  Google Scholar 

  7. Hoffmann, A., Levchenko, A., Scott, M.L. & Baltimore, D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 298, 1241–1245 (2002).

    Article  CAS  Google Scholar 

  8. Nelson, D.E. et al. Oscillations in NF-κB signaling control the dynamics of gene expression. Science 306, 704–708 (2004).

    Article  CAS  Google Scholar 

  9. Hao, S. & Baltimore, D. The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 10, 281–288 (2009).

    Article  CAS  Google Scholar 

  10. Ruland, J. Return to homeostasis: downregulation of NF-κB responses. Nat. Immunol. 12, 709–714 (2011).

    Article  CAS  Google Scholar 

  11. Lee, E.G. et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 289, 2350–2354 (2000).

    Article  CAS  Google Scholar 

  12. Taganov, K.D., Boldin, M.P., Chang, K.J. & Baltimore, D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481–12486 (2006).

    Article  CAS  Google Scholar 

  13. Boldin, M.P. et al. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J. Exp. Med. 208, 1189–1201 (2011).

    Article  CAS  Google Scholar 

  14. Zhao, J.L. et al. NF-κB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc. Natl. Acad. Sci. USA 108, 9814–9819 (2011).

    Google Scholar 

  15. Ben-Neriah, Y. & Karin, M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol. 12, 715–723 (2011).

    Article  CAS  Google Scholar 

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Correspondence to David Baltimore.

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Baltimore, D. NF-κB is 25. Nat Immunol 12, 683–685 (2011). https://doi.org/10.1038/ni.2072

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