An unexpected role for IL-17 in lymphoid organogenesis

In response to inhaled pathogens, lymphoid tissues can form in the lung. The driving force behind this organogenic process turns out to be interleukin 17–mediated activation of lung stromal cells.

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Figure 1: Organogenic functions of lymphotoxin and IL-17.

Katie Vicari

References

  1. 1

    van de Pavert, S.A. & Mebius, R.E. Nat. Rev. Immunol. 10, 664–674 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Randall, T.D. Adv. Immunol. 107, 187–241 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Rangel-Moreno, J. et al. Nat. Immunol. 12, 639–646 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Cupedo, T. et al. Nat. Immunol. 10, 66–74 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Mebius, R.E., Rennert, P. & Weissman, I.L. Immunity 7, 493–504 (1997).

    CAS  Article  Google Scholar 

  6. 6

    Eberl, G. et al. Nat. Immunol. 5, 64–73 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Yokota, Y. et al. Nature 397, 702–706 (1999).

    CAS  Article  Google Scholar 

  8. 8

    De Togni, P. et al. Science 264, 703–707 (1994).

    CAS  Article  Google Scholar 

  9. 9

    Harmsen, A. et al. J. Immunol. 168, 986–990 (2002).

    CAS  Article  Google Scholar 

  10. 10

    Fukuyama, S. et al. Immunity 17, 31–40 (2002).

    CAS  Article  Google Scholar 

  11. 11

    Iwakura, Y., Ishigame, H., Saijo, S. & Nakae, S. Immunity 34, 149–162 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Lotz, M. et al. J. Exp. Med. 203, 973–984 (2006).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Tom Cupedo.

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Cupedo, T. An unexpected role for IL-17 in lymphoid organogenesis. Nat Immunol 12, 590–592 (2011). https://doi.org/10.1038/ni.2058

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