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Return to homeostasis: downregulation of NF-κB responses

Nature Immunology volume 12, pages 709–714 (2011)Cite this article

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Abstract

Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.

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Figure 1: IκBα- and A20-dependent negative feedback loops in the canonical NF-κB pathway.
Figure 2: Dominant-negative adaptors.
Figure 3: Interference with NF-κB function in the nucleus.
Figure 4: Negative regulation of alternative NF-κB signaling.

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Acknowledgements

Supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich grants).

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  1. Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Jürgen Ruland

  2. Laboratory of Signaling in the Immune System, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany

    Jürgen Ruland

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Ruland, J. Return to homeostasis: downregulation of NF-κB responses. Nat Immunol 12, 709–714 (2011). https://doi.org/10.1038/ni.2055

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