La(s)t but not least

The T cell antigen receptor is functionally coupled to many kinases and adaptor proteins. Analysis of the spatiotemporal organization of the T cell antigen receptor signaling cascade suggests that adaptor-containing intracellular vesicles are essential for proper signal propagation.

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Figure 1: Models of TCR-proximal signaling components.

Katie Vicari

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Correspondence to Bernard Malissen.

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Malissen, B., Marguet, D. La(s)t but not least. Nat Immunol 12, 592–593 (2011). https://doi.org/10.1038/ni.2054

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