Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

La(s)t but not least

Nature Immunology volume 12, pages 592–593 (2011)Cite this article

Subjects

The T cell antigen receptor is functionally coupled to many kinases and adaptor proteins. Analysis of the spatiotemporal organization of the T cell antigen receptor signaling cascade suggests that adaptor-containing intracellular vesicles are essential for proper signal propagation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Models of TCR-proximal signaling components.

Katie Vicari

References

  1. Balagopalan, L., Coussens, N.P., Sherman, E., Samelson, L.E. & Sommers, C.L. Cold Spring Harb. Perspect. Biol. 2, a005512 (2010).

    Article  Google Scholar 

  2. Williamson, D.J. Nat. Immunol. 12, 655–662 (2011).

    Article  CAS  Google Scholar 

  3. Rust, M.J., Bates, M. & Zhuang, X. Nat. Methods 3, 793–795 (2006).

    Article  CAS  Google Scholar 

  4. Lillemeier, B.F. et al. Nat. Immunol. 11, 90–96 (2010).

    Article  CAS  Google Scholar 

  5. Bonello, G. et al. J. Cell Sci. 117, 1009–1016 (2004).

    Article  CAS  Google Scholar 

  6. Purbhoo, M.A. et al. Sci. Signal. 3, ra36 (2010).

    Article  Google Scholar 

  7. Alcover, A. & Thoulouze, M.I. Curr. Top. Microbiol. Immunol. 340, 191–207 (2010).

    CAS  PubMed  Google Scholar 

  8. Roncagalli, R., Mingueneau, M., Gregoire, C., Malissen, M. & Malissen, B. Trends Immunol. 31, 253–259 (2010).

    Article  CAS  Google Scholar 

  9. Mingueneau, M. et al. Immunity 31, 197–208 (2009).

    Article  CAS  Google Scholar 

  10. Chuck, M.I., Zhu, M., Shen, S. & Zhang, W. J. Immunol. 184, 2476–2486 (2010).

    Article  CAS  Google Scholar 

  11. Brdicka, T. et al. J. Exp. Med. 196, 1617–1626 (2002).

    Article  CAS  Google Scholar 

  12. Kohler, F. et al. Nat. Immunol. 6, 204–210 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bernard Malissen and Didier Marguet are at the Centre d'Immunologie de Marseille-Luminy, Université de la Méditerrannée, Institut National de la Santé et de la Recherche Médicale U631, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France.,

    Bernard Malissen & Didier Marguet

Authors
  1. Bernard Malissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Didier Marguet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bernard Malissen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malissen, B., Marguet, D. La(s)t but not least. Nat Immunol 12, 592–593 (2011). https://doi.org/10.1038/ni.2054

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2054

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing