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Dampening insulin signaling by an NLRP3 'meta-flammasome'

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The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.

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Figure 1: Involvement of the inflammasome in type 2 diabetes pathogenesis.

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  • 11 July 2011

    In the version of this article initially published, author Augustine Choi lacked an additional affiliation. The correct affiliations should include College of Medicine, Kyung Hee University, Seoul, Korea. This has been corrected in the HTML and PDF versions of the article.

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Correspondence to Augustine M K Choi.

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Choi, A., Nakahira, K. Dampening insulin signaling by an NLRP3 'meta-flammasome'. Nat Immunol 12, 379–380 (2011). https://doi.org/10.1038/ni.2028

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