Studies have suggested involvement of interleukin 17 (IL-17) in autoimmune diseases, although its effect on B cell biology has not been clearly established. Here we demonstrate that IL-17 alone or in combination with B cell–activating factor controlled the survival and proliferation of human B cells and their differentiation into immunoglobulin-secreting cells. This effect was mediated mainly through the nuclear factor-κB-regulated transcription factor Twist-1. In support of the relevance of our observations and the potential involvement of IL-17 in B cell biology, we found that the serum of patients with systemic lupus erythematosus had higher concentrations of IL-17 than did the serum of healthy people and that IL-17 abundance correlated with the disease severity of systemic lupus erythematosus.
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We thank H. Mitchison and G. Hinkal for critical reading of the manuscript; C. Delprat and G. Salles for scientific discussions; the laboratory of A. Puisieux (INSERM U590) for anti-Twist-1 as well as the Twist-1- and Twist-2-related vectors; and C. Bella for cell sorting. Supported by INSERM, UCB Lyon 1, the Arthritis Fondation Courtin (A.D.), the Association pour la Recherche sur le Cancer and the Ligue Contre le Cancer (07 and 26).
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Doreau, A., Belot, A., Bastid, J. et al. Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol 10, 778–785 (2009). https://doi.org/10.1038/ni.1741
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