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Integration of cytokine and heterologous receptor signaling pathways

Nature Immunology volume 10, pages 333–339 (2009)Cite this article

A Corrigendum to this article was published on 01 June 2009

This article has been updated

Abstract

Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.

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Figure 1: Classical and alternative view of cytokine-mediated regulation of cell functions.
Figure 2: Proposed models for triggering of tyrosine kinase–associated receptors.
Figure 3: Some predicted cytokine–heterologous receptor cross-talk points.

Change history

  • 18 May 2009

    NOTE: In the version of this article initially published, the second funding attribution in Acknowledgments is incorrect. The correct attribution is as follows: “Supported by Howard Hughes Medical Institute (J.S.B. and R.M.) and Damon Runyon Cancer Research Foundation (J.S.B).” The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We apologize to the many authors whose work we could not cite directly because of space limitations. We thank N. Palm, L. Kopp and I. Brodsky for discussions and reading of the manuscript. Supported by Howard Hughes Medical Institute (J.S.B. and R.M.) and Damon Runyon Cancer Research Foundation (J.S.B.).

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  1. Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA

    Jelena S Bezbradica & Ruslan Medzhitov

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Correspondence to Jelena S Bezbradica or Ruslan Medzhitov.

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Bezbradica, J., Medzhitov, R. Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol 10, 333–339 (2009). https://doi.org/10.1038/ni.1713

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