Estimated proportions of the FRR attributable to different types of genetic variation. (a -c) FRR estimates are shown for breast (a), ovarian (b) and prostate (c) cancers. The listed genes refer to genes with known disease-causing mutations (broadly categorized as those conferring high risk (for example, BRCA1 and BRCA2), other genes conferring high risk (for example, TP53) and genes conferring moderate risk (for example, PALB2). Pre-iCOGS SNPs refers to the contribution of all published SNPs associated with this cancer before the current COGS publications; iCOGS SNPs refers to the contribution of SNPs established in the current COGS publications (these totals are noted in Table 1). For breast cancer only, other iCOGS estimated refers to the estimated contribution of all other SNPs on the iCOGS array that were selected for replication of GWAS2.