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Repair by retrotransposition

Nature Genetics volume 31, pages 126–127 (2002)Cite this article

LINE-1 elements, an abundant class of mammalian transposable elements, can insert at sites of double-stranded DNA breaks. Do they promote the repair process or take advantage of it?

Retrotransposons are common components of all eukaryotic genomes. They generate duplicate copies of themselves, and sometimes other genes, by reverse transcribing RNA transcripts. With over 40% of our DNA directly attributed to these retrotransposition events1, the human genome provides ample evidence for the abundance of these sequences.

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  1. Department of Biology, University of Rochester, Rochester, 14627, New York, USA

    Thomas H. Eickbush

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  1. Thomas H. Eickbush
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Eickbush, T. Repair by retrotransposition. Nat Genet 31, 126–127 (2002). https://doi.org/10.1038/ng897

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