Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Early death of mice cloned from somatic cells


Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Early death of cloned mice.


  1. Ogura, A. et al. Biol. Reprod. 62, 1579–1584 (2000).

    CAS  Article  Google Scholar 

  2. Kimura, Y. & Yanagimachi, R. Development 121, 2397–2405 (1995).

    CAS  PubMed  Google Scholar 

  3. Renard, J.P. et al. Lancet 353, 1489–1491 (1999).

    CAS  Article  Google Scholar 

  4. Keefer, C.L. et al. Biol. Reprod. 64, 849–856 (2001).

    CAS  Article  Google Scholar 

  5. Miller, R.A. Int. Rev. Cytol. 124, 187–215 (1991).

    CAS  Article  Google Scholar 

  6. Fein, A.M. Clin. Infect. Dis. 28, 726–729 (1999).

    CAS  Article  Google Scholar 

  7. Antonini, J.M. et al. Chest 120, 240–249 (2001).

    CAS  Article  Google Scholar 

  8. Wakayama, T. et al. Nature 407, 318–319 (2000).

    CAS  Article  Google Scholar 

  9. Tian, X.C., Xu, J. & Yang, X. Nature Genet. 26, 272–273 (2000).

    CAS  Article  Google Scholar 

  10. Tamashiro, K.L.K. et al. Biol. Reprod. 63, 328–334 (2000).

    CAS  Article  Google Scholar 

  11. Weir, D.M. Handbook of Experimental Immunology (Blackwell, Oxford, UK, 1973).

    Google Scholar 

Download references


This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology; the Ministry of Health, Labor and Welfare; and the Human Science Foundation of Japan.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Atsuo Ogura.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ogonuki, N., Inoue, K., Yamamoto, Y. et al. Early death of mice cloned from somatic cells. Nat Genet 30, 253–254 (2002).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing