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Early death of mice cloned from somatic cells

Abstract

Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

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Figure 1: Early death of cloned mice.

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Acknowledgements

This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology; the Ministry of Health, Labor and Welfare; and the Human Science Foundation of Japan.

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Correspondence to Atsuo Ogura.

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The authors declare no competing financial interests.

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Ogonuki, N., Inoue, K., Yamamoto, Y. et al. Early death of mice cloned from somatic cells. Nat Genet 30, 253–254 (2002). https://doi.org/10.1038/ng841

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