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Alternative splicing and genome complexity


Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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Figure 1: EST estimations of alternative splicing from different eurkaryotes.
Figure 2: Dependence of alternative splicing prediction on EST coverage.


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Brett, D., Pospisil, H., Valcárcel, J. et al. Alternative splicing and genome complexity. Nat Genet 30, 29–30 (2002).

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