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Alternative splicing and genome complexity

Nature Genetics volume 30, pages 2930 (2002) | Download Citation

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Abstract

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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Author information

Affiliations

  1. Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125 Germany.

    • David Brett
    • , Heike Pospisil
    • , Jens Reich
    •  & Peer Bork
  2. European Molecular Biology Laboratory, Meyerhofstr. 1, 69012 Heidelberg, Germany.

    • Juan Valcárcel
    •  & Peer Bork

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DOI

https://doi.org/10.1038/ng803

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