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Small changes in expression affect predisposition to tumorigenesis

Nature Genetics volume 30, pages 2526 (2002) | Download Citation

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Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Acknowledgements

This work was supported by grants from the National Institutes of Health.

Author information

Affiliations

  1. The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

    • Hai Yan
    • , Kathy Romans
    • , Francis M. Giardiello
    • , Kenneth W. Kinzler
    •  & Bert Vogelstein
  2. Research Group Human Genetics, Department of Research, University Hospital, 4031 Basel, Switzerland.

    • Zuzana Dobbie
  3. Division of Molecular Medicine and Genetics, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan 48109, USA.

    • Stephen B. Gruber
  4. Howard Hughes Medical Institute, Department of Medicine and Ireland Cancer Center, Case Western Reserve University, University Hospitals of Cleveland and the Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.

    • Sanford Markowitz

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Corresponding author

Correspondence to Bert Vogelstein.

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DOI

https://doi.org/10.1038/ng799

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