Small changes in expression affect predisposition to tumorigenesis

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Figure 1: Reduced expression of one allele in affected individuals with FAP.
Figure 2: Loss-of-heterozygosity analysis.

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Acknowledgements

This work was supported by grants from the National Institutes of Health.

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Correspondence to Bert Vogelstein.

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Yan, H., Dobbie, Z., Gruber, S. et al. Small changes in expression affect predisposition to tumorigenesis. Nat Genet 30, 25–26 (2002). https://doi.org/10.1038/ng799

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