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Small changes in expression affect predisposition to tumorigenesis


We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Figure 1: Reduced expression of one allele in affected individuals with FAP.
Figure 2: Loss-of-heterozygosity analysis.


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This work was supported by grants from the National Institutes of Health.

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Correspondence to Bert Vogelstein.

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Yan, H., Dobbie, Z., Gruber, S. et al. Small changes in expression affect predisposition to tumorigenesis. Nat Genet 30, 25–26 (2002).

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