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New models of collaboration in genome-wide association studies: the Genetic Association Information Network

The Genetic Association Information Network (GAIN) is a public-private partnership established to investigate the genetic basis of common diseases through a series of collaborative genome-wide association studies. GAIN has used new approaches for project selection, data deposition and distribution, collaborative analysis, publication and protection from premature intellectual property claims. These demonstrate a new commitment to shared scientific knowledge that should facilitate rapid advances in understanding the genetics of complex diseases.

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Acknowledgements

The authors express their appreciation to P. de Bakker for providing estimates of genomic coverage for the GAIN genotyping platforms. The Broad Institute Center for Genotyping and Analysis is supported by grant U54 RR020278-01 (S. Gabriel, principal investigator) from the National Center for Research Resources.

The complete list of authors (the GAIN Collaborative Research Group) is as follows: Teri A Manolio1, Laura Lyman Rodriguez1, Lisa Brooks1, Gonçalo Abecasis2, the Collaborative Association Study of Psoriasis, Dennis Ballinger3, Mark Daly4, Peter Donnelly5, Stephen V Faraone6, the International Multi-Center ADHD Genetics Project, Kelly Frazer3,7, Stacey Gabriel4, Pablo Gejman8, the Molecular Genetics of Schizophrenia Collaboration, Alan Guttmacher1, Emily L Harris1, Thomas Insel9, John R Kelsoe10, the Bipolar Genome Study, Eric Lander4, Norma McCowin11, Matthew D Mailman12,13, Elizabeth Nabel14, James Ostell13, Elizabeth Pugh15, Stephen Sherry13, Patrick F Sullivan16, the Major Depression Stage 1 Genomewide Association in Population-Based Samples Study, John F Thompson17, James Warram18, the Genetics of Kidneys in Diabetes (GoKinD) Study, David Wholley11, Patrice M Milos19, Francis S Collins1

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Correspondence to Teri A Manolio.

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D.B. is an employee of Perlegen Sciences, Inc. K.F. was an employee of Perlegen Sciences, Inc. within the last year. M.D.M. is an employee of Eli Lilly and Co. P.M.M. was an employee of Pfizer, Inc. within the past year, and is currently an employee of Helicos BioSciences Corp. J.F.T. is an employee of Pfizer, Inc.

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The GAIN Collaborative Research Group. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet 39, 1045–1051 (2007). https://doi.org/10.1038/ng2127

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