Goldstone, A.P. Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol. Metab. 15, 12–20 (2004).
Runte, M. et al. The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. Hum. Mol. Genet. 10, 2687–2700 (2001).
Bressler, J. et al. The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat. Genet. 28, 232–240 (2001).
Yang, T. et al. A mouse model for Prader-Willi syndrome imprinting-centre mutations. Nat. Genet. 19, 25–31 (1998).
Gerard, M., Hernandez, L., Wevrick, R. & Stewart, C.L. Disruption of the mouse necdin gene results in early post-natal lethality. Nat. Genet. 23, 199–202 (1999).
Pagliardini, S., Ren, J., Wevrick, R. & Greer, J.J. Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am. J. Pathol. 167, 175–191 (2005).
Tsai, T.F., Jiang, Y.H., Bressler, J., Armstrong, D. & Beaudet, A.L. Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. Hum. Mol. Genet. 8, 1357–1364 (1999).
Muscatelli, F. et al. Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum. Mol. Genet. 9, 3101–3110 (2000).
Ren, J. et al. Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J. Neurosci. 23, 1569–1573 (2003).
Boccaccio, I. et al. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Hum. Mol. Genet. 8, 2497–2505 (1999).
Lee, S. et al. Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype. Hum. Mol. Genet. 9, 1813–1819 (2000).
Lee, S., Walker, C.L. & Wevrick, R. Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain. Gene Expr. Patterns 3, 599–609 (2003).
Panda, S. et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109, 307–320 (2002).
Card, J.P. Pseudorabies virus and the functional architecture of the circadian timing system. J. Biol. Rhythms 15, 453–461 (2000).
Ibata, Y. et al. Functional morphology of the suprachiasmatic nucleus. Front. Neuroendocrinol. 20, 241–268 (1999).
Silver, R. & Schwartz, W.J. The suprachiasmatic nucleus is a functionally heterogeneous timekeeping organ. Methods Enzymol. 393, 451–465 (2005).
Yoo, S.H. et al. PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl. Acad. Sci. USA 101, 5339–5346 (2004).
Goldstone, A.P. The hypothalamus, hormones, and hunger: alterations in human obesity and illness. Prog. Brain Res. 153, 57–73 (2006).
Sakurai, T. Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis. Sleep Med. Rev. 9, 231–241 (2005).
Hara, J., Yanagisawa, M. & Sakurai, T. Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci. Lett. 380, 239–242 (2005).
Willie, J.T. et al. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38, 715–730 (2003).
Davies, W., Isles, A.R. & Wilkinson, L.S. Imprinted gene expression in the brain. Neurosci. Biobehav. Rev. 29, 421–430 (2005).
Keverne, E.B., Fundele, R., Narasimha, M., Barton, S.C. & Surani, M.A. Genomic imprinting and the differential roles of parental genomes in brain development. Brain Res. Dev. Brain Res. 92, 91–100 (1996).
Lefebvre, L. et al. Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nat. Genet. 20, 163–169 (1998).
Li, L. et al. Regulation of maternal behavior and offspring growth by paternally expressed Peg3. Science 284, 330–333 (1999).
Kontgen, F., Suss, G., Stewart, C., Steinmetz, M. & Bluethmann, H. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int. Immunol. 5, 957–964 (1993).
Herzog, E.D., Aton, S.J., Numano, R., Sakaki, Y. & Tei, H. Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons. J. Biol. Rhythms 19, 35–46 (2004).
Simmons, D.M., Arriza, J.L. & Swanson, L.W. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissue with radio-labeled single stranded RNA probe. J. Histotechnol. 12, 169–180 (1989).
Paxinos, G. & Tork, I. Neuroanatomical nomenclature. Trends Neurosci. 13, 169 (1990).