Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Variation in FTO contributes to childhood obesity and severe adult obesity

A Corrigendum to this article was published on 01 October 2007

This article has been updated

Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 × 10−26 in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: LD structure and association in the FTO region.

Change history

  • 26 September 2007

    In the version of this article initially published, the authors failed to acknowledge that recruitment of obese cases was supported by both Assistance-Publique Hôpitaux de Paris and Centre National de la Recherche Scientifique. This error has been corrected in the PDF version of the article.

References

  1. Peters, T., Ausmeier, K. & Ruther, U. Mamm. Genome 10, 983–986 (1999).

    Article  CAS  Google Scholar 

  2. Dina, C. et al. Science 315, 187 (2007).

    Article  CAS  Google Scholar 

  3. King, D.C. et al. Genome Res. 15, 1051–1060 (2005).

    Article  CAS  Google Scholar 

  4. Ott, J. Neurology 63, 955–958 (2004).

    Article  Google Scholar 

  5. Hercberg, S. et al. Arch. Intern. Med. 164, 2335–2342 (2004).

    Article  CAS  Google Scholar 

  6. Vu-Hong, T.A. et al. J. Clin. Endocrinol. Metab. 91, 2437–2440 (2006).

    Article  CAS  Google Scholar 

  7. Le Fur, S., Le Stunff, C. & Bougneres, P. Diabetes 51, S304–S307 (2002).

    Article  CAS  Google Scholar 

  8. Körner, A., Berndt, J., Stumvoll, M., Kiess, W. & Kovacs, P. J. Clin. Endocrinol. Metab. published online 20 February 2007 (doi:10.1210/jc.2006-2514).

    Article  Google Scholar 

  9. Nyholt, D.R. Am. J. Hum. Genet. 74, 765–769 (2004).

    Article  CAS  Google Scholar 

  10. Jacobson, P., Torgerson, J.S., Sjostrom, L. & Bouchard, C. Am. J. Epidemiol. 165, 101–108 (2007).

    Article  Google Scholar 

  11. Stratakis, C.A. et al. J. Clin. Endocrinol. Metab. 85, 3396–3401 (2000).

    CAS  PubMed  Google Scholar 

  12. Su, A.I. et al. Proc. Natl. Acad. Sci. USA 101, 6062–6067 (2004).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank M. Deweirder and F. Allegaert for DNA preparation and D.-A. Tregouet for discussions on statistics. This study was supported by the ANR Diabomics grant from the French National Agency for Research. Work on the German replication data set was supported by grants from the DFG (KFO 152: “Atherobesity”, project KO 3512/1–1 (TP 1) to A.K. and 1264/10–1 (TP5) to W.K.) and from the EC (“PIONEER” integrated project grant to W.K.). The Leipzig Schoolchildren project was supported by unrestricted grants from Pfizer Pharma and Novo Nordisk (W.K.).

Author information

Authors and Affiliations

Authors

Contributions

Contributions of each author are detailed in the Supplementary Note online.

Corresponding author

Correspondence to Christian Dina.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

LD in the FTO gene. (PDF 63 kb)

Supplementary Fig. 2

FTO gene expression in human tissues. (PDF 83 kb)

Supplementary Table 1

Assessment of putative functionality of SNPs. (PDF 40 kb)

Supplementary Table 2

Genotype distribution and association tests under the general and additive models. (PDF 43 kb)

Supplementary Table 3

Genotype counts, Hardy Weinberg tests and failed genotype rate. (PDF 36 kb)

Supplementary Table 4

Effect size estimation and quantitative trait associations. (PDF 42 kb)

Supplementary Table 5

Description of study populations. (PDF 32 kb)

Supplementary Table 6

LD with potentially associated SNPs. (PDF 38 kb)

Supplementary Methods (PDF 81 kb)

Supplementary Notes (PDF 62 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dina, C., Meyre, D., Gallina, S. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39, 724–726 (2007). https://doi.org/10.1038/ng2048

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng2048

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing