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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

Abstract

We report duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA). Among these families, the duplicated segments had a minimal size ranging from 0.58 to 6.37 Mb. Brains from individuals with APP duplication showed abundant parenchymal and vascular deposits of amyloid-β peptides. Duplication of the APP locus, resulting in accumulation of amyloid-β peptides, causes ADEOAD with CAA.

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Figure 1: APP locus duplication in five kindreds.
Figure 2: Immunochemical characterization of CAA and senile plaques in brain tissues of a patient from family F037.

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Acknowledgements

We thank A. Rossi, C. De La Rochebrochard and H. Moirot for cytogenetic materials, C. Duyckaerts and F. Letournel for brain tissue samples, F. Checler for antibodies to Aβ, J. Bou for technical assistance, A. Goldenberg, S. Jacquemont, E. De La Fournière, T. Dutoya, C. Thomas-Anterion and F. Pasquier for clinical evaluation of patients and M. Tosi for critical reading of the manuscript. A.R.-L. was supported by le Conseil Regional de Haute Normandie.

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Correspondence to Dominique Campion.

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The authors declare no competing financial interests.

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Rovelet-Lecrux, A., Hannequin, D., Raux, G. et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38, 24–26 (2006). https://doi.org/10.1038/ng1718

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