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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Abstract

We examined the coding sequence of 518 protein kinases, 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

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Figure 1: Breast cancer mutational spectra.

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Correspondence to Michael R Stratton.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Mutation data for the primary and secondary screen (PDF 47 kb)

Supplementary Table 2

Genes analysed in the primary and secondary screens (XLS 66 kb)

Supplementary Table 3

Samples. (PDF 40 kb)

Supplementary Table 4

Coding strand. (PDF 52 kb)

Supplementary Table 5

Pyrimidine strand. (PDF 51 kb)

Supplementary Methods (PDF 78 kb)

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Stephens, P., Edkins, S., Davies, H. et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37, 590–592 (2005). https://doi.org/10.1038/ng1571

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