Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Nature Genetics volume 37, pages 590–592 (2005)Cite this article

Abstract

We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Breast cancer mutational spectra.

Similar content being viewed by others

References

  1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. & Sudarsanam, S. Science 298, 1912–1934 (2002).

    Article  CAS  Google Scholar 

  2. Huang, M.E., Rio, A.G., Nicolas, A. & Kolodner, R.D. Proc. Natl. Acad. Sci. USA. 100, 11529–11534 (2003).

    Article  CAS  Google Scholar 

  3. Xiao, W., Fontanie, T., Bawa, S. & Kohalmi, L. Mutat. Res. 431, 155–165 (1999).

    Article  CAS  Google Scholar 

  4. Wagner, E. & Lykke-Andersen, J. J. Cell Sci. 115, 3033–3038 (2002).

    CAS  PubMed  Google Scholar 

  5. Persons, D.L., Borelli, K.A. & Hsu, P.H. Mod. Pathol. 10, 720–727 (1997).

    CAS  PubMed  Google Scholar 

  6. Wang, T.L. et al. Proc. Natl. Acad. Sci. USA 99, 3076–3080 (2002).

    Article  CAS  Google Scholar 

  7. Olivier, M. et al. Hum. Mutat. 19, 607–614 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, UK

    Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Michael R Stratton, P Andrew Futreal & Richard Wooster

  2. Ludwig Institute for Cancer Research, 74 Avenue Hippocrate, Brussels, B-1200, Belgium

    Francis Brasseur

  3. Institute of Cancer Research, Sutton, SM2 5NG, Surrey, UK

    Colin S Cooper & Michael R Stratton

  4. The Institute of Orthopaedics, Univeristy College London, Stanmore, Middlesex, UK

    Adrienne M Flanagan

  5. Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK

    Anthony Green

  6. Cancer Research UK Clinical Centre, St. James University Hospital, Leeds, LS9 7TF, UK

    Maggie Knowles

  7. Department of Pathology, The University of Hong Kong, Hong Kong

    Suet Y Leung & Siu T Yuen

  8. Josephine Nefkens Institute, Erasmus University, Rotterdam, Rotterdam, 3015 GE, The Netherlands

    Leendert H J Looijenga

  9. Division of Urology, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA

    Bruce Malkowicz

  10. Nazionale Tumori and FIRC Institute of Molecular Oncology, Milan, Italy

    Marco A Pierotti

  11. Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, 49503, Michigan, USA

    Bin Teh

  12. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Andrew G Nicholson

  13. Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK

    Sunil Lakhani

  14. Cancer Research UK Genetic Epidemiology Group, Strangeways Research Laboratories, Cambridge, CB1 4RN, UK

    Douglas F Easton

  15. University of Pennsylvania Cancer Centre, 421 Curie Boulevard, Philadelphia, 19104, Pennsylvania, USA

    Barbara L Weber

Authors
  1. Philip Stephens
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sarah Edkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Helen Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chris Greenman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charles Cox
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chris Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Graham Bignell
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jon Teague
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Raffaella Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Claire Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Sarah O'Meara
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Adrian Parker
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Patrick Tarpey
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Tim Avis
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Andy Barthorpe
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Lisa Brackenbury
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Gemma Buck
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Adam Butler
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Jody Clements
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Jennifer Cole
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Ed Dicks
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Ken Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Simon Forbes
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Matthew Gorton
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Kristian Gray
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Kelly Halliday
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Rachel Harrison
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Katy Hills
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Jonathon Hinton
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. David Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Vivienne Kosmidou
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Ross Laman
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Richard Lugg
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Andrew Menzies
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Janet Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Robert Petty
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. Keiran Raine
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. Rebecca Shepherd
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. Alexandra Small
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. Helen Solomon
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. Yvonne Stephens
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. Calli Tofts
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. Jennifer Varian
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. Anthony Webb
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. Sofie West
    View author publications

    You can also search for this author in PubMed Google Scholar

  46. Sara Widaa
    View author publications

    You can also search for this author in PubMed Google Scholar

  47. Andrew Yates
    View author publications

    You can also search for this author in PubMed Google Scholar

  48. Francis Brasseur
    View author publications

    You can also search for this author in PubMed Google Scholar

  49. Colin S Cooper
    View author publications

    You can also search for this author in PubMed Google Scholar

  50. Adrienne M Flanagan
    View author publications

    You can also search for this author in PubMed Google Scholar

  51. Anthony Green
    View author publications

    You can also search for this author in PubMed Google Scholar

  52. Maggie Knowles
    View author publications

    You can also search for this author in PubMed Google Scholar

  53. Suet Y Leung
    View author publications

    You can also search for this author in PubMed Google Scholar

  54. Leendert H J Looijenga
    View author publications

    You can also search for this author in PubMed Google Scholar

  55. Bruce Malkowicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  56. Marco A Pierotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  57. Bin Teh
    View author publications

    You can also search for this author in PubMed Google Scholar

  58. Siu T Yuen
    View author publications

    You can also search for this author in PubMed Google Scholar

  59. Andrew G Nicholson
    View author publications

    You can also search for this author in PubMed Google Scholar

  60. Sunil Lakhani
    View author publications

    You can also search for this author in PubMed Google Scholar

  61. Douglas F Easton
    View author publications

    You can also search for this author in PubMed Google Scholar

  62. Barbara L Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

  63. Michael R Stratton
    View author publications

    You can also search for this author in PubMed Google Scholar

  64. P Andrew Futreal
    View author publications

    You can also search for this author in PubMed Google Scholar

  65. Richard Wooster
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael R Stratton.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Mutation data for the primary and secondary screen (PDF 47 kb)

Supplementary Table 2

Genes analysed in the primary and secondary screens (XLS 66 kb)

Supplementary Table 3

Samples. (PDF 40 kb)

Supplementary Table 4

Coding strand. (PDF 52 kb)

Supplementary Table 5

Pyrimidine strand. (PDF 51 kb)

Supplementary Methods (PDF 78 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stephens, P., Edkins, S., Davies, H. et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37, 590–592 (2005). https://doi.org/10.1038/ng1571

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1571

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing